Literature summary extracted from

Le, M.; Lanaspa, M.; Cicerchi, C.; Rana, J.; Scholten, J.; Hunter, B.; Rivard, C.; Randolph, R.; Johnson, R.
Bioactivity-guided identification of botanical inhibitors of ketohexokinase (2016), PLoS ONE, 11, e0157458.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.1.3	alpha-/gamma-mangostin	-	Homo sapiens
2.7.1.3	cratoxyarborenone E	-	Homo sapiens
2.7.1.3	methoxy-isobavachalcone	-	Homo sapiens
2.7.1.3	additional information	extracts of Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis exhibit ketohexokinase inhibitory activity and block fructose-induced ATP depletion and fructose-induced elevation in triglyerides and uric acid	Homo sapiens
2.7.1.3	osthole	-	Homo sapiens
2.7.1.3	phloretin	Malus domestica extract, IC50 value 8.99.2 microg/mL	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.3	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.3	Hep-G2 cell	-	Homo sapiens	-

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.7.1.3	0.0002	-	37°C, pH 7.2	Homo sapiens	methoxy-isobavachalcone
2.7.1.3	0.0007	-	37°C, pH 7.2	Homo sapiens	osthole
2.7.1.3	0.001	-	37°C, pH 7.2	Homo sapiens	cratoxyarborenone E
2.7.1.3	0.0015	-	37°C, pH 7.2	Homo sapiens	alpha-/gamma-mangostin

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)